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Articles (32)
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X-ray Structure of a Monomeric Cyclophilin A-Cyclosporin A Crystal Complex at 2·1 Å Resolution

Vincent Mikol, Jörg Kallen, Gaston Pflügl, Malcolm D. Walkinshaw

Journal:

Journal of Molecular Biology

Année:

1993

Fichier:

PDF, 459 KB

1993

Crystal Structures of Human Factor Xa Complexed with Potent Inhibitors

Maignan, Sébastien, Guilloteau, Jean-Pierre, Pouzieux, Stéphanie, Choi-Sledeski, Yong Mi, Becker, Michael R., Klein, Scott I., Ewing, William R., Pauls, Henry W., Spada, Alfred P., Mikol, Vincent

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 427 KB

english, 2000

Conformational polymorphism in peptidic and nonpeptidic drug molecules

Paul Taylor, Vincent Mikol, Jörg Kallen, Peter Burkhard, Malcolm D. Walkinshaw

Journal:

Biopolymers

Année:

1996

Langue:

english

Fichier:

PDF, 659 KB

english, 1996

Experimental determination of water equilibration rates in the hanging drop method of protein crystallization

Vincent Mikol, Jean-Luc Rodeau, Richard Giegé

Journal:

Analytical Biochemistry

Année:

1990

Langue:

english

Fichier:

PDF, 911 KB

english, 1990

Crystal and molecular structure of allyl O-(sodium 3-deoxy-α-d-manno- 2-octulopyranosylonate)-(2 → 8)-O-(sodium 3-deoxy-α-d-manno- 2-octulopyranosidonate)-monohydrate

Vincent Mikol, Paul Kosma, Helmut Brade

Journal:

Carbohydrate Research

Année:

1994

Langue:

english

Fichier:

PDF, 485 KB

english, 1994

Diagnostic of protein crystallization by dynamic light scattering; an application to an aminoacyl-tRNA synthetase

Vincent Mikol, Pascale Vincendon, Gilbert Eriani, Ernest Hirsch, Richard Giegé

Journal:

Journal of Crystal Growth

Année:

1991

Langue:

english

Fichier:

PDF, 296 KB

english, 1991

Significance of crystal growth of proteins and nucleic acids in biology: Novel ways in crystallogenesis

Vincent Mikol, Jean-Luc Rodeau, Ernest Hirsch, Richard Giegé

Journal:

Journal of Crystal Growth

Année:

1990

Langue:

english

Fichier:

PDF, 493 KB

english, 1990

Crystal structure of the cyclophilin-like domain from the parasitic nematode Brugia malayi

Vincent Mikol, Dong Ma, Clotilde K.S. Carlow

Journal:

Protein Science

Année:

1998

Langue:

english

Fichier:

PDF, 4.69 MB

english, 1998

Phase diagram of a crystalline protein: Determination of the solubility of concanavalin A by a microquantitation assay

Vincent Mikol, Richard Giegé

Journal:

Journal of Crystal Growth

Année:

1989

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1989

Improved Binding Affinity for Cyclophilin A by a Cyclosporin Derivative Singly Modified at Its Effector Domain

Papageorgiou, Christos, Florineth, Andrea, Mikol, Vincent

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 653 KB

english, 1994

Crystallogenesis of proteins

Richard Giegé, Vincent Mikol

Journal:

Trends in Biotechnology

Année:

1989

Langue:

english

Fichier:

PDF, 805 KB

english, 1989

Conformational polymorphism of cyclosporin A

Danièle Altschuh, Werner Braun, Joerg Kallen, Vincent Mikol, Claus Spitzfaden, Jean-Claude Thierry, Olivier Vix, Malcolm D Walkinshaw, Kurt Wüthrich

Journal:

Structure

Année:

1994

Langue:

english

Fichier:

PDF, 1.30 MB

english, 1994

The Crystal Structures of the SH2 Domain of p56lckComplexed with Two Phosphonopeptides Suggest a Gated Peptide Binding Site

Vincent Mikol, Götz Baumann, Thomas H. Keller, Ute Manning, Mauro G.M. Zurini

Journal:

Journal of Molecular Biology

Année:

1995

Langue:

english

Fichier:

PDF, 791 KB

english, 1995

Crystal Structure of the SH2 Domain from the Adaptor Protein SHC: A Model for Peptide Binding Based on X-ray and NMR Data

Vincent Mikol, Götz Baumann, Mauro G.M. Zurini, Ulrich Hommel

Journal:

Journal of Molecular Biology

Année:

1995

Langue:

english

Fichier:

PDF, 1.75 MB

english, 1995

Crystal Structures of Apolipoprotein(a) Kringle IV37 Free and Complexed with 6-Aminohexanoic Acid and withp-Aminomethylbenzoic Acid: Existence of Novel and Expected Binding Modes

Vincent Mikol, Philip V. LoGrasso, Brian R. Boettcher

Journal:

Journal of Molecular Biology

Année:

1996

Langue:

english

Fichier:

PDF, 1014 KB

english, 1996

Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases

Sébastien Maignan, Jean-Pierre Guilloteau, Qing Zhou-Liu, Christine Clément-Mella, Vincent Mikol

Journal:

Journal of Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 2.62 MB

english, 1998

Conformational differences of an immunosuppressant peptolide in a single crystal and in a crystal complex with human cyclophilin A

Vincent Mikol, Paul Taylor, Joerg Kallen, Malcolm D. Walkinshaw

Journal:

Journal of Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 615 KB

english, 1998

X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A

Joerg Kallen, Vincent Mikol, Paul Taylor, Malcolm D.Walkinshaw

Journal:

Journal of Molecular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 1.10 MB

english, 1998

Crystallisation and preliminary X-ray diffraction studies of cyclophilin-tetrapeptide and cyclophilin-cyclosporin complexes

Mauro Zurini, Joerg Kallen, Vincent Mikol, Gaston Pfluegl, Johan N. Jansonius, Malcolm D. Walkinshaw

Journal:

FEBS Letters

Année:

1990

Langue:

english

Fichier:

PDF, 563 KB

english, 1990

The Crystal Structures of Four Peptide Deformylases Bound to the Antibiotic Actinonin Reveal Two Distinct Types: A Platform for the Structure-based Design of Antibacterial Agents

Jean-Pierre Guilloteau, Magali Mathieu, Carmela Giglione, Véronique Blanc, Alain Dupuy, Miline Chevrier, Patricia Gil, Alain Famechon, Thierry Meinnel, Vincent Mikol

Journal:

Journal of Molecular Biology

Année:

2002

Langue:

english

Fichier:

PDF, 840 KB

english, 2002

Cyclosporins : Structure-Activity Relationships

HANS FLIRI, GOETZ BAUMANN, ALBERT ENZ, JUERG KALLEN, MARCEL LUYTEN, VINCENT MIKOL, RAO MOVVA, VALERIE QUESNIAUX, MAX SCHREIER, MALCOLM WALKINSHAW, ROLAND WENGER, GERHARD ZENKE, MAURO ZURINI

Journal:

Annals of the New York Academy of Sciences

Année:

1993

Langue:

english

Fichier:

PDF, 365 KB

english, 1993

Engineering Protein Therapeutics: Predictive Performances of a Structure-Based Virtual Affinity Maturation Protocol

Oberlin, Michael, Kroemer, Romano, Mikol, Vincent, Minoux, Hervé, Tastan, Erdogan, Baurin, Nicolas

Journal:

Journal of Chemical Information and Modeling

Année:

2012

Langue:

english

Fichier:

PDF, 2.06 MB

english, 2012

Molecular Structures of Human Factor Xa Complexed with Ketopiperazine Inhibitors: Preference for a Neutral Group in the S1 Pocket

Maignan, Sébastien, Guilloteau, Jean-Pierre, Choi-Sledeski, Yong Mi, Becker, Michael R., Ewing, William R., Pauls, Henry W., Spada, Alfred P., Mikol, Vincent

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 540 KB

english, 2003

The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis with Cyclophilin A

Mikol, Vincent, Papageorgiou, Christos, Borer, Xaver

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 3.14 MB

english, 1995

Human Cyclophilin C: Primary Structure, Tissue Distribution, and Determination of Binding Specificity for Cyclosporins

Schneider, Helmut, Charara, Nadine, Schmitz, Rita, Wehrli, Susi, Mikol, Vincent, Zurini, Mauro G. M., Quesniaux, Valerie F. J., Movva, N. Rao

Journal:

Biochemistry

Année:

1994

Langue:

english

Fichier:

PDF, 2.04 MB

english, 1994

The X-ray structure of (MeBm 2 t) 1 -cyclosporin complexed with cyclophilin A provides an explanation for its anomalously high immunosuppressive activity

Mikol, Vincent, Kallen, Jörg, Walkinshaw, Malcolm D.

Journal:

Protein Engineering Design and Selection

Année:

1994

Langue:

english

Fichier:

PDF, 525 KB

english, 1994

The Use of 3D Structural Data in the Design of Specific Factor Xa Inhibitors

Maignan, Sebastien, Mikol, Vincent

Journal:

Current Topics in Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 377 KB

english, 2001

Escherichia coli FolC Structure Reveals an Unexpected Dihydrofolate Binding Site Providing an Attractive Target for Anti-microbial Therapy

Mathieu, M., Debousker, G., Vincent, S., Viviani, F., Bamas-Jacques, N., Mikol, V.

Journal:

Journal of Biological Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2005

X-Ray Structure of a Cyclophilin B/Cyclosporin Complex: Comparison with Cyclophilin A and Delineation of its Calcineurin-Binding Domain

Vincent Mikol, Jorg Kallen and Malcolm D. Walkinshaw

Journal:

Proceedings of the National Academy of Sciences

Année:

1994

Langue:

english

Fichier:

PDF, 715 KB

english, 1994

Papillary Tumor of the Pineal Region

Jouvet, Anne, Fauchon, François, Liberski, Pawel, Saint-Pierre, Ghislaine, Didier-Bazes, Marianne, Heitzmann, Anna, Delisle, Marie-Bernadette, Biassette, Homa Adle, Vincent, Sylvie, Mikol, Jacqueline,

Journal:

American Journal of Surgical Pathology

Année:

2003

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2003

Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque

Comoy, Emmanuel E., Mikol, Jacqueline, Jaffré, Nina, Lebon, Vincent, Levavasseur, Etienne, Streichenberger, Nathalie, Sumian, Chryslain, Perret-Liaudet, Armand, Eloit, Marc, Andreoletti, Olivier, Haïk

Journal:

Nature Communications

Année:

2017

Langue:

english

Fichier:

PDF, 2.18 MB

english, 2017

A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients

Cassotta, Antonino, Mikol, Vincent, Bertrand, Thomas, Pouzieux, Stéphanie, Le Parc, Josiane, Ferrari, Paul, Dumas, Jacques, Auer, Michael, Deisenhammer, Florian, Gastaldi, Matteo, Franciotta, Diego, S

Journal:

Nature Medicine

Année:

2019

Langue:

english

Fichier:

PDF, 6.95 MB

english, 2019